Aminoacyl-tRNA synthetases
MAR Gomez, M Ibba - Rna, 2020 - rnajournal.cshlp.org
The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
Emerging roles of tRNA in adaptive translation, signalling dynamics and disease
S Kirchner, Z Ignatova - Nature Reviews Genetics, 2015 - nature.com
Abstract tRNAs, nexus molecules between mRNAs and proteins, have a central role in
translation. Recent discoveries have revealed unprecedented complexity of tRNA …
translation. Recent discoveries have revealed unprecedented complexity of tRNA …
Translational fidelity and mistranslation in the cellular response to stress
Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …
Transfer RNA and human disease
JA Abbott, CS Francklyn, SM Robey-Bond - Frontiers in genetics, 2014 - frontiersin.org
Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and
result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are …
result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are …
Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy
A Götz, H Tyynismaa, L Euro, P Ellonen… - The American Journal of …, 2011 - cell.com
Infantile cardiomyopathies are devastating fatal disorders of the neonatal period or the first
year of life. Mitochondrial dysfunction is a common cause of this group of diseases, but the …
year of life. Mitochondrial dysfunction is a common cause of this group of diseases, but the …
Synthetic and editing mechanisms of aminoacyl-tRNA synthetases
JJ Perona, I Gruic-Sovulj - Aminoacyl-tRNA synthetases in biology and …, 2014 - Springer
Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
Mitochondrial aminoacyl-tRNA synthetases in human disease
S Konovalova, H Tyynismaa - Molecular Genetics and Metabolism, 2013 - Elsevier
Mitochondrial aminoacyl-tRNA synthetases (mtARSs) are essential in the process of
transferring genetic information from mitochondrial DNA to the complexes of the oxidative …
transferring genetic information from mitochondrial DNA to the complexes of the oxidative …
Cellular mechanisms that control mistranslation
Mistranslation broadly encompasses the introduction of errors during any step of protein
synthesis, leading to the incorporation of an amino acid that is different from the one …
synthesis, leading to the incorporation of an amino acid that is different from the one …
Quality control in aminoacyl-tRNA synthesis: its role in translational fidelity
SS Yadavalli, M Ibba - Advances in protein chemistry and structural biology, 2012 - Elsevier
Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …
Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
Mutations in genes encoding aminoacyl-tRNA synthetases are known to cause
leukodystrophies and genetic leukoencephalopathies—heritable disorders that result in …
leukodystrophies and genetic leukoencephalopathies—heritable disorders that result in …