Emerging evidence suggests that alterations in the development of the gastrointestinal (GI)
tract during the early postnatal period can influence brain development and vice-versa. It is …

Numerous epidemiological studies in the human population clearly indicate that smoking
while pregnant has deleterious effects on fetal development as well as long-term adverse …

The gut-brain axis describes a complex interplay between the central nervous system and
organs of the gastrointestinal tract. Sensory neurons of dorsal root and nodose ganglia …

Homomeric α7 nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in the
central and peripheral nervous system (CNS and PNS, respectively), and spinal cord. In …

Smoking is a documented risk factor for cancer, eg, gastric cancer. Nicotine, the principal
tobacco alkaloid, would exert its role of contribution to gastric cancer development and …

Introduction: The ability of nicotine, the primary psychoactive substance in tobacco smoke, to
regulate appetite and body weight is one of the factors cited by smokers that prevents them …

Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of
neurotransmission in the enteric nervous system (ENS). In this study, we examined the …

Four drugs are currently approved for the treatment of Alzheimer's disease (AD) by the FDA.
Three of these drugs—donepezil, rivastigmine, and galantamine—belong to the class of …

Cigarette smoking during pregnancy is the largest modifiable risk factor for adverse
outcomes in the infant. Investigations have focused on the psychoactive component of …

Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)
were originally found as synapse-associated protein 90/postsynaptic density protein-95 …