The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

This review describes the additions of allylmagnesium reagents to carbonyl compounds and
to imines, focusing on the differences in reactivity between allylmagnesium halides and …

Mechanistic and computational studies were conducted to elucidate the mechanism and the
origins of enantiocontrol for asymmetric chiral phosphoric acid-catalyzed spiroketalization …

We describe the design and development of the first catalytic asymmetric vinylogous Prins
cyclization. This reaction constitutes an efficient approach for highly diastereo-and …

We recently demonstrated that chiral cyclopropenimines are viable Brønsted base catalysts
in enantioselective Michael and Mannich reactions. Herein, we describe a series of structure …

Chiral phosphoric acid-catalyzed enantioselective aza-Friedel–Crafts reaction of
trifluoromethyl benzoxazinones with pyrroles is reported. Under mild conditions, a range of …

In recent years, the field of organocatalysis has extensively explored the use of carbenium
ions for practical C− C bond forming reactions. In order to control the formation of new …

Computational studies of three chiral phosphoric-acid-catalyzed asymmetric ring-openings
of meso-epoxides show that the enantioselectivity of these reactions stems from favorable …