Transcriptional and post-transcriptional gene regulation by long non-coding RNA

IM Dykes, C Emanueli - Genomics, Proteomics and …, 2017 - academic.oup.com
Advances in genomics technology over recent years have led to the surprising discovery
that the genome is far more pervasively transcribed than was previously appreciated. Much …

Interplay between miRNAs and host genes and their role in cancer

B Liu, Y Shyr, J Cai, Q Liu - Briefings in functional genomics, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-
transcriptionally regulate gene expression. They play essential roles in nearly all biological …

Oncogenic long noncoding RNA landscape in breast cancer

S Xu, D Kong, Q Chen, Y Ping, D Pang - Molecular cancer, 2017 - Springer
Abstract Background Few long noncoding RNAs (lncRNAs) that act as oncogenic genes in
breast cancer have been identified. Methods Oncogenic lncRNAs associated with …

miR‐15a‐5p, miR‐15b‐5p, and miR‐16‐5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

S Chava, CP Reynolds, AS Pathania… - Molecular …, 2020 - Wiley Online Library
Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite
current aggressive treatment regimens, the prognosis for high‐risk NB patients remains …

miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche

B Li, Y Xia, J Lv, W Wang, Z Xuan, C Chen, T Jiang… - Oncogene, 2021 - nature.com
Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …

Role of circular RNA DLEU2 in human acute myeloid leukemia

DM Wu, X Wen, XR Han, S Wang… - … and cellular biology, 2018 - Am Soc Microbiol
In the current study, we were interested in exploring the molecular mechanism of circular
RNA DLEU2 (circRNA-DLEU2)(hsa_circ_0000488) and microRNA 496 (miR-496), as well …

Platelet RNA signatures for the detection of cancer

N Sol, T Wurdinger - Cancer and Metastasis Reviews, 2017 - Springer
Platelets are equipped with RNA processing machineries, such as pre-mRNA splicing, pre-
miRNA processing, and mRNA translation. Since platelets are devoid of a nucleus, most …

Circular RNAs in acute myeloid leukemia

V Singh, MH Uddin, JA Zonder, AS Azmi… - Molecular cancer, 2021 - Springer
Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated
the development of several novel targeted therapeutics, most AML patients still relapse …

miRNA-15a/16: as tumor suppressors and more

E Huang, R Liu, Y Chu - Future oncology, 2015 - Taylor & Francis
Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been
reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This …

Clinical significance of microRNAs in hematologic malignancies and hematopoietic stem cell transplantation

A Sevcikova, I Fridrichova, N Nikolaieva, L Kalinkova… - Cancers, 2023 - mdpi.com
Simple Summary Dysregulated microRNA (miRNA) expression has been described in the
initiation and progression of a wide spectrum of hematologic malignancies. Moreover …