Fungal plasma membrane domains

A Athanasopoulos, B Andre… - FEMS microbiology …, 2019 - academic.oup.com
The plasma membrane (PM) performs a plethora of physiological processes, the
coordination of which requires spatial and temporal organization into specialized domains of …

The wide‐ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories

EJ Johnston, T Moses, SJ Rosser - Yeast, 2020 - Wiley Online Library
Yeast strains have been used extensively as robust microbial cell factories for the production
of bulk and fine chemicals, including biofuels (bioethanol), complex pharmaceuticals …

Manipulating cell flocculation-associated protein kinases in Saccharomyces cerevisiae enables improved stress tolerance and efficient cellulosic ethanol production

PL Ye, XQ Wang, B Yuan, CG Liu, XQ Zhao - Bioresource technology, 2022 - Elsevier
Cell self-flocculation endows yeast strains with improved environmental stress tolerance that
benefits bioproduction. Exploration of the metabolic and regulatory network differences …

TORC2 controls endocytosis through plasma membrane tension

M Riggi, C Bourgoint, M Macchione, S Matile… - Journal of Cell …, 2019 - rupress.org
Target of rapamycin complex 2 (TORC2) is a conserved protein kinase that regulates
multiple plasma membrane (PM)–related processes, including endocytosis. Direct, chemical …

The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae

FM Roelants, KL Leskoske, MN Martinez Marshall… - Biomolecules, 2017 - mdpi.com
To grow, eukaryotic cells must expand by inserting glycerolipids, sphingolipids, sterols, and
proteins into their plasma membrane, and maintain the proper levels and bilayer distribution …

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

M Karuppasamy, B Kusmider, TM Oliveira… - Nature …, 2017 - nature.com
The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes,
conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 …

Genome-wide analysis of AGC kinases reveals that MoFpk1 is required for development, lipid metabolism, and autophagy in hyperosmotic stress of the rice blast …

MH Wu, Q Yu, TY Tao, LX Sun, H Qian, XM Zhu, L Li… - Mbio, 2022 - Am Soc Microbiol
During eukaryotic evolution, the TOR-AGC kinase signaling module is involved in the
coordinated regulation of cell growth and survival. However, the AGC kinases in plant …

Phospho‐regulation of intrinsically disordered proteins for actin assembly and endocytosis

Y Miao, T Tipakornsaowapak, L Zheng, Y Mu… - The FEBS …, 2018 - Wiley Online Library
Actin filament assembly contributes to the endocytic pathway pleiotropically, with active roles
in clathrin‐dependent and clathrin‐independent endocytosis as well as subsequent …

Flipping the script: Advances in understanding how and why P4-ATPases flip lipid across membranes

AC Norris, AJ Mansueto, M Jimenez… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Type IV P-type ATPases (P4-ATPases) are a family of transmembrane enzymes that
translocate lipid substrates from the outer to the inner leaflet of biological membranes and …

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2

KL Leskoske, FM Roelants… - Genes & …, 2018 - genesdev.cshlp.org
Saccharomyces cerevisiae target of rapamycin (TOR) complex 2 (TORC2) is an essential
regulator of plasma membrane lipid and protein homeostasis. How TORC2 activity is …