New developments in the pathogenesis, therapeutic targeting, and treatment of pediatric medulloblastoma

FY Fang, JS Rosenblum, WS Ho, JD Heiss - Cancers, 2022 - mdpi.com
Simple Summary Medulloblastoma is the most common pediatric brain tumor, comprising
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …

lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m6A …

J Wang, L Tan, X Yu, X Cao, B Jia, R Chen, J Li - Molecular Cancer, 2022 - Springer
Rationale Lung cancer is the most prevalent form of cancer and has a high mortality rate,
making it a global public health concern. The N6-methyladenosine (m6A) modification is a …

[HTML][HTML] Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells

Q Fernandes, L Therachiyil, AQ Khan, T Bedhiafi… - European Journal of …, 2023 - Elsevier
Cancer remains one of the leading causes of mortality worldwide, presenting a significant
healthcare challenge owing to the limited efficacy of current treatments. The application of …

Nanoparticle-mediated co-delivery of Notch-1 antibodies and ABT-737 as a potent treatment strategy for triple-negative breast cancer

DM Valcourt, MN Dang, MA Scully, ES Day - ACS nano, 2020 - ACS Publications
Triple-negative breast cancer (TNBC) accounts for nearly one-quarter of all breast cancer
cases, but effective targeted therapies for this disease remain elusive because TNBC cells …

Dual regulation of miR-34a and Notch signaling in triple-negative breast cancer by antibody/miRNA nanocarriers

DM Valcourt, ES Day - Molecular Therapy-Nucleic Acids, 2020 - cell.com
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
expression of the three most common receptors present on other subtypes, leaving it …

[HTML][HTML] Knockdown of lncRNA ZNRD1-AS1 suppresses gastric cancer cell proliferation and metastasis by targeting the miR-9-5p/HSP90AA1 axis

MC Ba, Z Ba, YF Gong, KP Lin, YB Wu, YN Tu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
LncRNAs play an important role in a variety of biological processes, such as cancer
pathogenesis. The lncRNA zinc ribbon domain containing 1 antisense RNA 1 (ZNRD1-AS1) …

[HTML][HTML] Unveiling the dynamic interplay between cancer stem cells and the tumor microenvironment in melanoma: implications for novel therapeutic strategies

P Limonta, R Chiaramonte, L Casati - Cancers, 2024 - mdpi.com
Simple Summary Resistance to standard therapies represents a major challenge in
melanoma treatment. This is mainly related to the high heterogeneity of this malignancy due …

The complexity of the tumor microenvironment and its role in acute lymphoblastic leukemia: implications for therapies

C Simioni, I Conti, G Varano, C Brenna… - Frontiers in …, 2021 - frontiersin.org
The microenvironment that surrounds a tumor, in addition to the tumor itself, plays an
important role in the onset of resistance to molecularly targeted therapies. Cancer cells and …

Biological studies of new implant materials based on carbon and polymer carriers with film heterostructures containing noble metals

SI Dorovskikh, ES Vikulova, DS Sergeevichev… - Biomedicines, 2022 - mdpi.com
This paper presents pioneering results on the evaluation of noble metal film hetero-
structures to improve some functional characteristics of carbon-based implant materials …

Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma

M Caimano, L Lospinoso Severini, E Loricchio… - Frontiers in …, 2021 - frontiersin.org
Medulloblastoma (MB) is a highly aggressive pediatric tumor of the cerebellum.
Hyperactivation of the Hedgehog (HH) pathway is observed in about 30% of all MB …