Hepatotoxicity due to herbal dietary supplements: Past, present and the future
Dietary supplements (DS) constitute a widely used group of products comprising vitamin,
mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) …
mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) …
Recent advances in mass spectrometry (MS)-based glycoproteomics in complex biological samples
Protein glycosylation plays a key role in various biological processes and disease-related
pathological progression. Mass spectrometry (MS)-based glycoproteomics is a powerful …
pathological progression. Mass spectrometry (MS)-based glycoproteomics is a powerful …
A drug screen using human iPSC-derived hepatocyte-like cells reveals cardiac glycosides as a potential treatment for hypercholesterolemia
Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been
hampered by the lack of models. However, cells with hepatocyte characteristics can be …
hampered by the lack of models. However, cells with hepatocyte characteristics can be …
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Deeper understanding of liver pathophysiology would benefit from a comprehensive
quantitative proteome resource at cell type resolution to predict outcome and design …
quantitative proteome resource at cell type resolution to predict outcome and design …
Decellularized human liver extracellular matrix (hDLM)‐mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs)
Liver tissue engineering has emerged as a promising approach in organ transplantation but
has been hampered by the lack of a reliable and readily available cell source. Human …
has been hampered by the lack of a reliable and readily available cell source. Human …
Surfaceome mapping of primary human heart cells with CellSurfer uncovers cardiomyocyte surface protein LSMEM2 and proteome dynamics in failing hearts
L Berg Luecke, M Waas, J Littrell… - Nature cardiovascular …, 2023 - nature.com
Cardiac cell surface proteins are drug targets and useful biomarkers for discriminating
among cellular phenotypes and disease states. Here we developed an analytical platform …
among cellular phenotypes and disease states. Here we developed an analytical platform …
Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state
Esophageal adenocarcinoma (EAC) is one of the most frequent causes of cancer death, and
yet compared to other common cancers, we know relatively little about the molecular …
yet compared to other common cancers, we know relatively little about the molecular …
Veneer Is a Webtool for Rapid, Standardized, and Transparent Interpretation, Annotation, and Reporting of Mammalian Cell Surface N-Glycocapture Data
L Berg Luecke, R Mesidor, J Littrell… - Journal of proteome …, 2024 - ACS Publications
Currently, no consensus exists regarding criteria required to designate a protein within a
proteomic data set as a cell surface protein. Most published proteomic studies rely on varied …
proteomic data set as a cell surface protein. Most published proteomic studies rely on varied …
SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates
M Waas, ST Snarrenberg, J Littrell… - …, 2020 - academic.oup.com
Motivation Cell-type-specific surface proteins can be exploited as valuable markers for a
range of applications including immunophenotyping live cells, targeted drug delivery and in …
range of applications including immunophenotyping live cells, targeted drug delivery and in …
Human pluripotent stem cell-derived hepatocyte-like cells and organoids for liver disease and therapy
Y Li, X Yang, R Plummer, Y Hayashi, XS Deng… - International Journal of …, 2021 - mdpi.com
Liver disease is a global health issue that has caused an economic burden worldwide.
Organ transplantation is the only effective therapy for end-stage liver disease; however, it …
Organ transplantation is the only effective therapy for end-stage liver disease; however, it …