Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …

Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Delivery of genetic information to the interior of target cells in vivo has been a major
challenge facing gene therapies. This barrier is now being overcome, owing in part to …

Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …

Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …

Liposomes, which possess the properties of nano-scale, biofilm similar structure, excellent
biocompatibility, become more and more useful in the drug development as the delivery …

Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …

Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …