Obesity has become a major risk factor for the development of chronic diseases such as
insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity …

DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

Brain cellular heterogeneity may bias cell type specific DNA methylation patterns,
influencing findings in psychiatric epigenetic studies. We performed fluorescence activated …

In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …

The G 4 C 2 repeat expansion in C9orf72 is the most common known cause of amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). We tested the …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

We investigated whether ancestral liver damage leads to heritable reprogramming of
hepatic wound healing in male rats. We found that a history of liver damage corresponds …

Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of
diabetes in offspring. However, the mechanisms involved and the possibilities of …

Exacerbation of macrophage-mediated inflammation contributes to pathogenesis of various
inflammatory diseases, but the immunometabolic programs underlying regulation of …

Transforming growth factor-beta (TGF-β), a key mediator of cardiac fibroblast activation, has
a major influence on collagen type I production. However, the epigenetic mechanisms by …