Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up
within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result …

Spatial omics emerged as a new frontier of biological and biomedical research. Here, we
present spatial-CUT&Tag for spatially resolved genome-wide profiling of histone …

Background Chromatin accessibility is crucial for gene expression regulation in specific cells
and in multiple biological processes. Assay for Transposase Accessible Chromatin with high …

Background ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing)
is a recently developed technique for genome-wide analysis of chromatin accessibility …

A variety of single-cell RNA preparation procedures have been described. So far, protocols
require fresh material, which hinders complex study designs. We describe a sample …

Chromatin regulatory landscape plays a critical role in many disease processes and embryo
development. Epigenome sequencing technologies such as chromatin immunoprecipitation …

Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem
(iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …

A myriad of diseases is caused or characterized by alteration of epigenetic patterns,
including changes in DNA methylation, post-translational histone modifications, or chromatin …

Neurodegenerative diseases are challenging for systems biology because of the lack of
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …

Evolutionary studies are often limited by missing data that are critical to understanding the
history of selection. Selection experiments, which reproduce rapid evolution under …