Familial hypercholesterolaemia (FH) is a common autosomal semi-dominant and highly
penetrant disorder of the low-density lipoprotein (LDL) receptor pathway, characterised by …

Abstract Purpose of Review This review aims to summarize the existing research on sex
differences in familial hypercholesterolemia (FH) across the lifespan. Recent Findings From …

Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary
syndromes (ACS) are substantial contributors to morbidity and mortality across Europe …

Polygenic risk scores (PRSs) hold promise for disease risk assessment and prevention. The
Genomic Medicine at Veterans Affairs (GenoVA) Study is addressing three main challenges …

Abstract Purpose of Review The UK National Health Service (NHS) has recently announced
a Newborn Genomes Programme (NGP) to identify infants with treatable inherited disorders …

Atherosclerosis is characterized by the narrowing of the arterial lumen due to subendothelial
lipid accumulation, with hypercholesterolemia being a major risk factor. Despite the recent …

Abstract Purpose of Review It is clear from epidemiological studies that patients at high and
very-high risk of atherosclerotic cardiovascular diseases (ASCVD) risk do not reach lipid …

Screening for familial hypercholesterolemia (FH) in childhood remains controversial.
Existing guidelines offer practitioners conflicting advice despite generally agreeing on the …

Aims Familial hypercholesterolaemia (FH) patients are subjected to a high lifetime exposure
to low density lipoprotein cholesterol (LDL-C), despite use of lipid-lowering therapy (LLT) …

Background Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of
death in the United States. Case-based learning using electronic delivery of the modules …