Structural basis for human Cav3.2 inhibition by selective antagonists
The Cav3. 2 subtype of T-type calcium channels has been targeted for developing
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …
Pathology of pain and its implications for therapeutic interventions
B Cao, Q Xu, Y Shi, R Zhao, H Li, J Zheng… - … and Targeted Therapy, 2024 - nature.com
Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …
health and economic burdens. Effective pain management is crucial for individuals suffering …
Dissection of the structure–function relationship of Nav channels
Z Li, Q Wu, G Huang, X Jin, J Li… - Proceedings of the …, 2024 - National Acad Sciences
Voltage-gated sodium channels (Nav) undergo conformational shifts in response to
membrane potential changes, a mechanism known as the electromechanical coupling. To …
membrane potential changes, a mechanism known as the electromechanical coupling. To …
Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors
Y Wei, Z Yu, L Wang, X Li, N Li, Q Bai, Y Wang… - Nature …, 2024 - nature.com
The voltage-gated calcium channel CaV1. 2 is essential for cardiac and vessel smooth
muscle contractility and brain function. Accumulating evidence demonstrates that …
muscle contractility and brain function. Accumulating evidence demonstrates that …
Structural biology of voltage-gated calcium channels
Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane
depolarization, playing critical roles in diverse physiological processes. Dysfunction or …
depolarization, playing critical roles in diverse physiological processes. Dysfunction or …