Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

We report the discovery of an unusual halohydrin dehalogenase, HHDHamb, that can work
under relatively low acidic conditions and extremely low temperatures for the bio‐nitration of …

A solvothermal reaction of Cd (II) with the dicarboxyl-functionalized arylhydrazone pro-
ligands, 5-(2-(2, 4, 6-trioxotetrahydro-pyrimidin-5 (2H)-ylidene) hydrazineyl) isophthalic acid …

Hydroxynitrile lyases (HNLs) primarily catalyze the stereoselective synthesis of
cyanohydrins, but some of them also carry out asymmetric nitroaldol synthesis (Henry …

Arabidopsis thaliana hydroxynitrile lyase (AtHNL) engineering has uncovered variants that
showed up to 12-fold improved catalytic efficiency than the wild-type towards asymmetric …

Diastereoselective Henry reaction (DHR) is an effective direct C–C bond ligation
transformation that enables the synthesis of β-nitroalcohols having two contiguous chiral …

Protein engineering to improve promiscuous catalytic activity is important for biocatalytic
application of enzymes in green synthesis. We uncovered the significance of binding site …

Chiral quaternary phosphonium ion-pair catalysis showcases a distinctive catalytic and
stereoinductive mode arising from the synergy between ionic and noncovalent interactions …

Biocatalytic asymmetrization of inexpensive and stable primary alcohols to prepare
enantioenriched β‐nitroalcohols is an important development in green chemistry for the …

Granulicella tundricola hydroxynitrile lyase (Gt HNL) catalyses the synthesis of chiral (R)-
cyanohydrins and (R)-β-nitro alcohols. The triple variant Gt HNL-A40H/V42T/Q110H (Gt …