Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal
hypothalamus (MBH), but the components of this microgliosis and its metabolic …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the
loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine …

With severe injury or disease, microglia become chronically activated and damage the local
brain environment, likely contributing to cognitive decline. We previously discovered that …

Extensive microglia reactivity has been well described in human and experimental temporal
lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular …

Microglia are the first responders to intracerebral hemorrhage, but their precise role in
intracerebral hemorrhage remains to be defined. Microglia are the only type of brain cells …

Extracellular alpha-synuclein (αsyn) oligomers, associated to exosomes or free, play an
important role in the pathogenesis of Parkinson's disease (PD). Increasing evidence …

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease
affecting primarily the upper and lower motor neurons. A common feature of all ALS cases is …