It has been controversial that men carrying a DNA mismatch repair (MMR) gene mutation
(Lynch syndrome) are at heightened risk of prostate cancer given that an increased risk is …

At a time where the incidence of colorectal cancer, a disease predominantly of developed
nations, is showing a decline in those 50 years of age and older, data from the West is …

Purpose Prostate cancer has been described as a component tumor of Lynch syndrome
(LS), with tumors obtained from mutation carriers demonstrating the DNA mismatch repair …

Background A possible role for prostate cancer in Lynch syndrome has been debated based
on observations of mismatch-repair defective tumors and reports of an increased risk of …

Objective Lynch syndrome is an inherited genetic disorder associated with a predisposition
to early-onset colorectal and endometrial cancers, but breast cancer risk in these patients is …

The spectrum of cancers seen in a hospital based Lynch syndrome registry of mismatch
repair gene mutation carriers was examined to determine the distribution of cancers and …

Background: In Lynch syndrome, inherited mismatch repair (MMR) defects predispose to
colorectal cancer and to a wide spectrum of extra-colorectal tumours. Utilising a cohort study …

Inherited defects in the DNA mismatch repair (MMR) system, MLH1, MSH2, MSH6, and
PMS2 genes, underlie Lynch syndrome, one of the most prevalent cancer syndromes in …

Lynch syndrome has classically been defined by several predominant malignancies. Initial
clinical criteria for diagnosis of Lynch syndrome would miss 40% of affected individuals. As …

Recent studies have suggested that breast cancer is part of the tumor spectrum in Lynch
syndrome (LS). However, the frequency and significance of DNA mismatch repair (MMR) …