Role of epigenetic mechanisms in cisplatin-induced toxicity
Cisplatin (CDDP) is a highly effective antineoplastic agent, widely used in the treatment of
various malignant tumors. However, its major problems are side effects associated to …
various malignant tumors. However, its major problems are side effects associated to …
Relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs: A meta-analysis
F Lv, Y Ma, Y Zhang, Z Li - The International Journal of …, 2018 - journals.sagepub.com
Although many previous studies have reported the relationship between GSTP1 rs1695
gene polymorphism and myelosuppression induced by platinum-based drugs, the …
gene polymorphism and myelosuppression induced by platinum-based drugs, the …
Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms
X Deng, J Hou, Q Deng, Z Zhong - World Journal of Surgical Oncology, 2020 - Springer
Background Fluoropyrimidines and platinum are still widely used for colorectal cancer
(CRC) management. Several studies have reported that mutations of dihydropyrimidine …
(CRC) management. Several studies have reported that mutations of dihydropyrimidine …
GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation
EC Pincinato, EFD Costa, L Lopes-Aguiar… - Scientific reports, 2019 - nature.com
Cisplatin (CDDP) combined with radiotherapy (RT) is employed in head and neck
squamous cell carcinoma (HNSCC) with variable toxicities and clinical response …
squamous cell carcinoma (HNSCC) with variable toxicities and clinical response …
Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study
T Fujikawa, T Ito, R Okada, M Sawada, K Mohri… - Hearing Research, 2024 - Elsevier
Objective The genotype-phenotype relationship in cisplatin-induced ototoxicity remains
unclear. By assessing early shifts in distortion product otoacoustic emission (DPOAE) levels …
unclear. By assessing early shifts in distortion product otoacoustic emission (DPOAE) levels …
Association between ABCC2 polymorphism and hematological toxicity in patients with esophageal cancer receiving platinum plus 5-fluorouracil therapy
K Fujita, S Motoyama, Y Sato, A Wakita, Y Nagaki… - Esophagus, 2022 - Springer
Background Platinum agents are taken up into cells by copper transporter (CTR) 1 (gene
code: SLC31A1) and are excreted from cells by copper-transporting P-type adenosine …
code: SLC31A1) and are excreted from cells by copper-transporting P-type adenosine …
[HTML][HTML] Glutathione S-transferase polymorphisms in head and neck squamous cell carcinoma treated with chemotherapy and/or radiotherapy
MP Maniglia, A Russo, PM Biselli-Chicote… - Asian Pacific journal …, 2020 - ncbi.nlm.nih.gov
Methods: The GST gene polymorphisms were evaluated in 197 cases and 514 controls by
PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism …
PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism …
[HTML][HTML] Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma
DGL Moreira, EF Morais, HBP Santos… - Brazilian Oral …, 2020 - SciELO Brasil
The DNA repair system involves genes and proteins that are essential for the maintenance
of genome integrity and the consequent control of various cellular processes. Alterations in …
of genome integrity and the consequent control of various cellular processes. Alterations in …
[HTML][HTML] Association analysis of apoptosis-related gene caspase3, Integrin a subunit 1 and glutathione sulfur transferase M1 gene polymorphisms and susceptibility to …
R Wang, Z Zhang, D Li, N Wu… - Journal of Medical …, 2023 - ncbi.nlm.nih.gov
Background To explore the association of polymorphisms of apoptosis-linked genes
caspase3 (CASP3), integrin a subunit 1 (ITGA1), glutathione sulfur transferase M1 (GSTM1) …
caspase3 (CASP3), integrin a subunit 1 (ITGA1), glutathione sulfur transferase M1 (GSTM1) …
Cost-minimization analysis of GSTP1c.313A>G genotyping for the prevention of cisplatin-induced nausea and vomiting: A Bayesian inference approach
Background Chemotherapy-induced nausea and vomiting are concerning adverse events
resulting from cancer treatment, and current guidelines recommend the use of neurokinin-1 …
resulting from cancer treatment, and current guidelines recommend the use of neurokinin-1 …