The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Insulin resistance is a multi-faceted disruption of the communication between insulin and the
interior of a target cell. The underlying cause of insulin resistance appears to be …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

OBJECTIVE Obesity alters gut microbiota ecology and associates with low-grade
inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most …

Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

Although weight loss can usually be achieved by restricting food intake, the majority of
dieters regain weight over the long-term. In the hypothalamus, hormonal signals from the …

Abstract Glucagon-like peptide-1 (7–36) amide (GLP-1) is a secreted peptide that acts as a
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …

This review highlights evidence for a role of the vagus nerve in the development of obesity
and how targeting the vagus nerve with neuromodulation or pharmacology can be used as a …

Context: Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2
diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves …