[HTML][HTML] Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
[HTML][HTML] Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies
AM Crooks, R Bateson, AB Cope… - The Journal of …, 2015 - academic.oup.com
The quantitative viral outgrowth assay (QVOA) provides a precise minimal estimate of the
reservoir of resting CD4+ T-cell infection (resting cell infection [RCI]). However, the variability …
reservoir of resting CD4+ T-cell infection (resting cell infection [RCI]). However, the variability …
Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane
Z Wang, EE Gurule, TP Brennan… - Proceedings of the …, 2018 - National Acad Sciences
The latent reservoir for HIV-1 in resting CD4+ T cells is a major barrier to cure. Several lines
of evidence suggest that the latent reservoir is maintained through cellular proliferation …
of evidence suggest that the latent reservoir is maintained through cellular proliferation …
Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases
Background: It is unknown whether the reduction in HIV-1 reservoirs seen after allogeneic
hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to …
hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to …
[HTML][HTML] Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
[HTML][HTML] Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
JK Bui, MD Sobolewski, BF Keele, J Spindler… - PLoS …, 2017 - journals.plos.org
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
HIV latency
RF Siliciano, WC Greene - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
[HTML][HTML] Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
A Halper-Stromberg, CL Lu, F Klein, JA Horwitz… - Cell, 2014 - cell.com
Latent reservoirs of HIV-1-infected cells are refractory to antiretroviral therapies (ART) and
remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …
remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …