The epidemic of opioid addiction is shaping up as the most serious clinical issues of current
times. Opioids have the greatest propensity to develop addiction after first exposure …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Background Like other complex diseases including drug addiction, genetic factors can
interfere with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) …

The United States is experiencing an epidemic of opioid use disorder (OUD) and overdose-
related deaths. However, the genetic basis for the ability to discontinue opioid use has not …

Background: Opioids are widely used as an analgesic for the treatment of moderate to
severe pain. However, there are interindividual variabilities in opioid response. Current …

The use of mu-opioid receptor (MOP-r) agonists such as oxycodone together with cocaine is
prevalent, and deaths attributed to using these combinations have increased. Rationale: It is …

Background Drug addiction is a serious problem worldwide and is influenced by genetic
factors. The present study aimed to investigate the association between genetics and drug …

The study aimed to examine the genetic contribution to buprenorphine (BUP) treatment in
individuals with opioid use disorder (OUD), with a specific focus on BDNF and OPRM1 …

This paper is the forty-first consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The widely abused prescription opioid oxycodone is a mu-opioid receptor (MOP-r) agonist
and addiction to such opioids is a relapsing disorder. The human MOP-r gene (OPRM1) has …