Choline, an essential dietary nutrient for humans, is required for the synthesis of the
neurotransmitter, acetylcholine, the methyl group donor, betaine, and phospholipids; and …

DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …

Methyl groups are important for numerous cellular functions such as DNA methylation,
phosphatidylcholine synthesis, and protein synthesis. The methyl group can directly be …

Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is
synthesized from methionine as an important intermediate in the one-carbon pathway. High …

Genetic or nutritional disturbances in one-carbon metabolism, with associated
hyperhomocysteinemia, can result in complex disorders including pregnancy complications …

Choline has several important functions. These are as follows: 1) it is a source of the methyl
groups needed to make the primary methyl donor S-adenosylmethionine, 2) it is a part of the …

Nausea and vomiting in pregnancy (NVP) is one of the most common uncomfortable
symptoms of women in early pregnancy. A total of 303 Chinese pregnant women from 10 …

BACKGROUND The incidence of neural tube defects has diminished considerably since the
implementation of food fortification with folic acid (FA). However, the impact of excess FA …

Homocysteine in pregnancy Page 120 ADVANCES IN CLINICAL CHEMISTRY, VOL. 53
HOMOCYSTEINE IN PREGNANCY Michelle M. Murphy*,†, 1 and Joan D. Fernandez-Ballart*,† …

Riboflavin (vitamin B2 found in food) is a precursor of flavin mononucleotide (FMN) and
flavin adenine dinucleotide (FAD), which study as coenzymes for a variety of cellular …