Cisplatin for cancer therapy and overcoming chemoresistance

R Ranasinghe, ML Mathai, A Zulli - Heliyon, 2022 - cell.com
Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

Extraction and purification of phycobiliproteins from algae and their applications

G Kovaleski, M Kholany, LMS Dias, SFH Correia… - Frontiers in …, 2022 - frontiersin.org
Microalgae, macroalgae and cyanobacteria are photosynthetic microorganisms, prokaryotic
or eukaryotic, living in saline or freshwater environments. These have been recognized as …

Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic

B Ortega-Domínguez, OE Aparicio-Trejo… - Food and Chemical …, 2017 - Elsevier
Cisplatin is widely used as chemotherapeutic agent for treatment of diverse types of cancer,
however, acute kidney injury (AKI) is an important side effect of this treatment. Diverse …

Ginsenoside Rg5 ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis

W Li, MH Yan, Y Liu, Z Liu, Z Wang, C Chen, J Zhang… - Nutrients, 2016 - mdpi.com
Although cisplatin is an effective anti-cancer agent that is widely used for treating various
types of malignant solid tumors, the nephrotoxicity induced by cisplatin severely limits its …

Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics

OE Aparicio‐Trejo, E Tapia, E Molina‐Jijón… - Biofactors, 2017 - Wiley Online Library
Abstract Five‐sixths nephrectomy (5/6NX) is a widely used model to study the mechanisms
leading to renal damage in chronic kidney disease (CKD). However, early alterations on …

C-phycocyanin mitigates cognitive impairment in doxorubicin-induced chemobrain: impact on neuroinflammation, oxidative stress, and brain mitochondrial and …

C Wang, Y Zhao, L Wang, S Pan, Y Liu, S Li… - Neurochemical …, 2021 - Springer
Chemotherapy-induced cognitive impairment (CICI) is a common detrimental effect of
cancer treatment, occurring in up to 75% of cancer patients. The widely utilized …

c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism

H Madhyastha, R Madhyastha, A Thakur… - Colloids and Surfaces B …, 2020 - Elsevier
Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research
over the last few years. In the present investigation, we have reported temperature …

Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury

ZN Ma, YZ Li, W Li, XT Yan, G Yang, J Zhang… - International Journal of …, 2017 - mdpi.com
Although cisplatin is an anticancer drug that has activity against malignant tumor, it often
causes nephrotoxicity. Previous reports have confirmed that the saponins from the leaves of …

Chemobrain: A review on mechanistic insight, targets and treatments

V Rao, R Bhushan, P Kumari, SP Cheruku… - Advances in cancer …, 2022 - Elsevier
Chemo-brain refers to the thinking and memory problems that occur in cancer patients
during and after chemotherapy. It is also known as cognitive dysfunction or chemo-fog. Risk …

Platycodin D suppresses cisplatin‐induced cytotoxicity by suppressing ROS‐mediated oxidative damage, apoptosis, and inflammation in HEK‐293 cells

J Hu, J Leng, Q Shen, Y Liu, X Li… - … of Biochemical and …, 2021 - Wiley Online Library
Cisplatin, a proven effective chemotherapeutic agent, has been used clinically to treat
malignant solid tumors, whereas its clinical use is limited by serious side effect including …