Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …

Rationale: Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and
MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive …

Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized
by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+ …

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Even mild pulmonary hypertension (PH) is associated with increased mortality and morbidity
in patients with chronic obstructive pulmonary disease (COPD). However, the underlying …

Chronic Obstructive Pulmonary Disease (COPD) is one of the foremost causes of death
worldwide. It is primarily caused by tobacco smoke, making it an easily preventable disease …

Rationale: Little is known about what drives the appearance of lymphoid follicles (LFs),
which may function as lymphoid organs in chronic obstructive pulmonary disease (COPD) …

Aminoacyl-tRNA synthetases (ARSs) are an important class of enzymes with an
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …

With effective antiretroviral therapy (ART), cardiovascular diseases (CVD) are emerging as a
major cause of morbidity and death in the aging HIV-infected population. To address …