The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …

Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways
that play key roles for tissue maintenance. In particular, it is important in the context of …

The BCL-2 family of proteins integrates signals that trigger either cell survival or apoptosis.
The balance between pro-survival and pro-apoptotic proteins is important for tissue …

Simple Summary In patients with stage III colon cancer, adjuvant chemotherapy with a
fluoropyrimidine combined with oxaliplatin reduces the risk of recurrence and mortality, with …

Purpose: SMAD4 has shown promise in identifying patients with colorectal cancer at high
risk of recurrence or death. Experimental Design: A discovery cohort and independent …

Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …

One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to
profile genetic dependencies in cancer cell lines. Here, we describe data from a series of …

SMAD4 is an essential mediator in the transforming growth factor-β pathway. Sporadic
mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are …

Simple Summary Stage II colon cancer is defined as an early stage of the tumor disease,
without the involvement of lymph nodes or distant organs. In this group of patients, surgery …

Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …