Software tools for automated transmission electron microscopy

M Schorb, I Haberbosch, WJH Hagen, Y Schwab… - Nature …, 2019 - nature.com
The demand for high-throughput data collection in electron microscopy is increasing for
applications in structural and cellular biology. Here we present a combination of software …

IgG antibody 3D structures and dynamics

JW Jay, B Bray, Y Qi, E Igbinigie, H Wu, J Li, G Ren - Antibodies, 2018 - mdpi.com
Antibodies are vital for human health because of their ability to function as nature's drugs by
protecting the body from infection. In recent decades, antibodies have been used as …

LoTToR: an algorithm for missing-wedge correction of the low-tilt tomographic 3D reconstruction of a single-molecule structure

X Zhai, D Lei, M Zhang, J Liu, H Wu, Y Yu, L Zhang… - Scientific reports, 2020 - nature.com
A single-molecule three-dimensional (3D) structure is essential for understanding the
thermal vibrations and dynamics as well as the conformational changes during the chemical …

Rapid generation of metal–organic framework phase diagrams by high-throughput transmission electron microscopy

X Gong, K Gnanasekaran, K Ma… - Journal of the …, 2022 - ACS Publications
Metal–organic frameworks (MOFs) constructed from Zr6 nodes and tetratopic carboxylate
linkers display high structural diversity and complexity in which various crystal topologies …

An automated scanning transmission electron microscope guided by sparse data analytics

M Olszta, D Hopkins, KR Fiedler, M Oostrom… - Microscopy and …, 2022 - cambridge.org
Artificial intelligence (AI) promises to reshape scientific inquiry and enable breakthrough
discoveries in areas such as energy storage, quantum computing, and biomedicine …

Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography

D Lei, AE Marras, J Liu, CM Huang, L Zhou… - Nature …, 2018 - nature.com
Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate
functional nanomachines by programming the folding of a single-stranded DNA template …

Non-averaged single-molecule tertiary structures reveal RNA self-folding through individual-particle cryo-electron tomography

J Liu, EKS McRae, M Zhang, C Geary… - Nature …, 2024 - nature.com
Large-scale and continuous conformational changes in the RNA self-folding process
present significant challenges for structural studies, often requiring trade-offs between …

Unlimited acquisition time in electron holography by automated feedback control of transmission electron microscope

C Gatel, J Dupuy, F Houdellier, MJ Hÿtch - Applied Physics Letters, 2018 - pubs.aip.org
The signal-to-noise ratio of measurements by electron holography could be considerably
improved if longer exposure times were possible: increasing the number of electrons …

Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP)

M Zhang, X Zhai, J Li, JJ Albers, S Vuletic… - Biochimica et Biophysica …, 2018 - Elsevier
Human phospholipid transfer protein (PLTP) mediates the transfer of phospholipids among
atheroprotective high-density lipoproteins (HDL) and atherogenic low-density lipoproteins …

Tertiary structure of single-instant RNA molecule reveals folding landscape

J Liu, EKS McRae, M Zhang, C Geary, ES Andersen… - bioRxiv, 2023 - biorxiv.org
The folding of RNA and protein molecules during their synthesis is a crucial self-assembly
process that nature employs to convert genetic information into the complex molecular …