Highlights•Integrins are subject to complex regulation by signalling and trafficking
molecules.•Integrin activation occurs from inside and outside of the cell.•Integrins can …

Following spinal cord injury (SCI), a multitude of intrinsic and extrinsic factors adversely
affect the gene programs that govern the expression of regeneration-associated genes …

After axotomy, neuronal survival and growth cone re-formation are required for axon
regeneration. We discovered that doublecortin-like kinases (DCLKs), members of the …

Water temperature is an important environmental parameter influencing the distribution and
the health of fishes and it plays a central role in ectothermic animals. The aim of this study is …

Injury to the brain and spinal cord has devastating consequences because adult central
nervous system (CNS) axons fail to regenerate. Injury to the peripheral nervous system …

Peripheral nerve injury is a common injury disease. Understanding of the mechanisms of
periphery nerve repair and regeneration after injury is an essential prerequisite for treating …

Rabies virus (RABV) is a widespread pathogen that causes fatal disease in humans and
animals. It has been suggested that multiple host factors are involved in RABV host entry …

Anisotropic alginate hydrogels with microchannels can provide a substrate for
cotransplanted cells and for axons in the injured spinal cord by physically guiding …

After traumatic injuries to the nervous system, regrowing axons encounter a complex
microenvironment where mechanisms that promote regeneration compete with inhibitory …

Chondroitin sulfate proteoglycans (CSPGs), up-regulated in and around the glial scar after
mammalian spinal cord injury, have been suggested to be key inhibitory molecules for …