Applications of oxetanes in drug discovery and medicinal chemistry
G Huang, D Hucek, T Cierpicki, J Grembecka - European Journal of …, 2023 - Elsevier
The compact and versatile oxetane motifs have gained significant attention in drug discovery
and medicinal chemistry programs. This review presents an overview of the diverse …
and medicinal chemistry programs. This review presents an overview of the diverse …
Cathepsins in bacteria-macrophage interaction: defenders or victims of circumstance?
L Szulc-Dąbrowska, M Bossowska-Nowicka… - Frontiers in cellular …, 2020 - frontiersin.org
Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …
and digesting pathogens through phagocytosis leading to initiation of the innate …
Peptidomimetic α-acyloxymethylketone warheads with six-membered lactam P1 glutamine mimic: SARS-CoV-2 3CL protease inhibition, coronavirus antiviral activity …
B Bai, A Belovodskiy, M Hena… - Journal of Medicinal …, 2021 - ACS Publications
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a
necessity to develop direct-acting antivirals that can be readily administered and are active …
necessity to develop direct-acting antivirals that can be readily administered and are active …
Cardiac pericytes mediate the remodeling response to myocardial infarction
P Quijada, S Park, P Zhao, KSS Kolluri… - The Journal of …, 2023 - Am Soc Clin Investig
Despite the prevalence of pericytes in the microvasculature of the heart, their role during
ischemia-induced remodeling remains unclear. We used multiple lineage-tracing mouse …
ischemia-induced remodeling remains unclear. We used multiple lineage-tracing mouse …
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors
Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants
being observed around the globe new therapeutics, particularly direct-acting antivirals that …
being observed around the globe new therapeutics, particularly direct-acting antivirals that …
[HTML][HTML] Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S
TJ Harryvan, M Visser, L De Bruin, L Plug… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Cross-presentation of exogenous antigens in HLA-class I molecules by
professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent …
professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent …
Anti-Inflammatory and Antiatopic Effects of Rorippa cantoniensis (Lour.) Ohwi in RAW 264.7 and HaCaT Cells
MJ Kim, BS Hwang, Y Hwang, YT Jeong, DW Jeong… - Molecules, 2023 - mdpi.com
This study evaluated the effects of Rorippa cantoniensis (Lour.) ohwi extract (RCE) on
factors associated with inflammation-related skin lesions in RAW 264.7 and HaCaT cells …
factors associated with inflammation-related skin lesions in RAW 264.7 and HaCaT cells …
Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers
Background Systemic and local profiles have each been associated with asthma, but
parsing causal relationships between system-wide and airway-specific processes can be …
parsing causal relationships between system-wide and airway-specific processes can be …
[HTML][HTML] Therapeutic potential of targeting cathepsin S in pulmonary fibrosis
YJ Yoo, E Choi, Y Kim, Y Cha, E Um, Y Kim… - Biomedicine & …, 2022 - Elsevier
Cathepsin S (CTSS), a lysosomal protease, belongs to a family of cysteine cathepsin
proteases that promote degradation of damaged proteins in the endolysosomal pathway …
proteases that promote degradation of damaged proteins in the endolysosomal pathway …
Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models
Simple Summary Oral cancer is often deadly and severely painful. Because this form of
cancer pain cannot be adequately treated with current medications including opiates, new …
cancer pain cannot be adequately treated with current medications including opiates, new …