Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity
M Kazempour-Dizaji, S Mojtabavi, A Sadri… - Bioorganic …, 2023 - Elsevier
Because of the colossal global burden of diabetes, there is an urgent need for more effective
and safer drugs. We designed and synthesized a new series of aurone derivatives …
and safer drugs. We designed and synthesized a new series of aurone derivatives …
Bio-oriented synthesis of novel polyhydroquinoline derivatives as α-glucosidase inhibitor for management of diabetes
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches
Type II diabetes mellitus (T2DM) is a global health issue with high rate of prevalence. The
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
Design, Synthesis, characterization and biological screening of novel thiosemicarbazones and their derivatives with Potent Antibacterial and Antidiabetic Activities
Thiosemicarbazones and their derivatives were synthesized by reacting carbonyl
compounds with thiosemicarbazide, followed by treatment with metal salts. The prepared …
compounds with thiosemicarbazide, followed by treatment with metal salts. The prepared …
Synthesis, in vitro α-glucosidase and α-amylase activities and molecular docking study of oxadiazole-sulphonamide hybrid analogues
Acarbose and voglibose are two different α-glucosidase and α-amylase inhibitors that are
used to manage diabetes mellitus. Sadly, these renowned and therapeutically effective …
used to manage diabetes mellitus. Sadly, these renowned and therapeutically effective …
Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors
Inhibiting α‐glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies
The current studies mainly demonstrate the coumarin based azomethine-clubbed thiazoles
synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the …
synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the …
Development of coumarin tagged 1, 2, 3-triazole derivatives targeting α-glucosidase inhibition: Synthetic modification, biological evaluation, kinetic and in silico …
Coumarin derivatives have been demonstrated as promising anti-diabetic compounds
through α-glucosidase inhibition. This is a ubiquitous brush border membrane-bound …
through α-glucosidase inhibition. This is a ubiquitous brush border membrane-bound …
Pyrano [2, 3-b] chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies
E Farzaneh, M Mohammadi, P Raymand, M Noori… - Bioorganic …, 2024 - Elsevier
Inhibition of α-glucosidase and α-amylase is an important target for treatment of type 2
diabetes. In this work, a novel series of pyrano [2, 3-b] chromene derivatives 5a-m was …
diabetes. In this work, a novel series of pyrano [2, 3-b] chromene derivatives 5a-m was …