Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

A dual-targeted metal–organic framework based nanoplatform for the treatment of rheumatoid arthritis by restoring the macrophage niche

S Tao, H Yu, T You, X Kong, X Wei, Z Zheng, L Zheng… - ACS …, 2023 - ACS Publications
Inflammatory infiltration and bone destruction are important pathological features of
rheumatoid arthritis (RA), which originate from the disturbed niche of macrophages. Here …

Network analysis and transcriptome profiling identify autophagic and mitochondrial dysfunctions in SARS-CoV-2 infection

K Singh, YC Chen, S Hassanzadeh, K Han… - Frontiers in …, 2021 - frontiersin.org
Analyzing host cells' transcriptional response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying …

Polycystic ovary syndrome and recurrent pregnancy loss, a review of literature

R Wartena, M Matjila - Frontiers in Endocrinology, 2023 - frontiersin.org
Objective PCOS is a syndrome of ovarian dysfunction associated with recurrent pregnancy
loss. Several correlating factors have been investigated that influence the risk of pregnancy …

Inflammation‐instructed hierarchical delivery of IL‐4/miR‐21 orchestrates osteoimmune microenvironment toward the treatment of rheumatoid arthritis

Y Deng, Y Zhou, Q Liang, C Ge, J Yang… - Advanced Functional …, 2021 - Wiley Online Library
Dysregulated inflammation and failure in resolution account for the incidence and
deterioration of rheumatoid arthritis (RA). IL‐4 and miR‐21 possess complementary …

C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance

X Lei, MM Seldin, HC Little, N Choy, T Klonisch… - Journal of Biological …, 2017 - ASBMB
Obesity is associated with chronic low-grade inflammation, and metabolic regulators linking
obesity to inflammation have therefore received much attention. Secreted C1q/TNF-related …

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets

H Nording, L Baron, D Haberthür… - Nature …, 2021 - nature.com
Platelets contribute to the regulation of tissue neovascularization, although the specific
factors underlying this function are unknown. Here, we identified the complement …

[HTML][HTML] MiR-29b-3p promotes particulate matter-induced inflammatory responses by regulating the C1QTNF6/AMPK pathway

J Wang, M Zhu, L Ye, C Chen, J She, Y Song - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Inflammatory responses are considered to be the critical mechanism underlying particulate
matter (PM)-induced development and exacerbation of chronic respiratory diseases. MiR …

Circulating levels of C1q/TNF‐α‐related protein 6 (CTRP6) in polycystic ovary syndrome

A Sadeghi, R Fadaei, N Moradi, FZ Fouani… - Iubmb …, 2020 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting
females of reproductive age. It has been associated with cardiometabolic disorders …

CPSF6 is a clinically relevant breast cancer vulnerability target: role of CPSF6 in breast cancer

N Binothman, IY Hachim, JJ Lebrun, S Ali - EBioMedicine, 2017 - thelancet.com
Breast cancer represents a major health challenge. The majority of breast cancer deaths are
due to cancer progression/recurrence for which no efficient therapies exist. Aggressive …