Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities
PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
[HTML][HTML] The role of inflammation in age-related macular degeneration
W Tan, J Zou, S Yoshida, B Jiang… - International journal of …, 2020 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is a blinding eye disease which incidence
gradually increases with age. Inflammation participates in AMD pathogenesis, including …
gradually increases with age. Inflammation participates in AMD pathogenesis, including …
[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …
is a major cause of blindness. Even while central visual acuity remains relatively well …
Microglia in the retina: roles in development, maturity, and disease
SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Geographic atrophy is a blinding form of age-related macular degeneration characterized by
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration
H Heloterä, K Kaarniranta - Cells, 2022 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with a limited understanding of its pathogenesis and the number of …
aging population with a limited understanding of its pathogenesis and the number of …
A new era in posterior segment ocular drug delivery: Translation of systemic, cell-targeted, dendrimer-based therapies
Vision impairment and loss due to posterior segment ocular disorders, including age-related
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …
[HTML][HTML] Hyperreflective foci, optical coherence tomography progression indicators in age-related macular degeneration, include transdifferentiated retinal pigment …
D Cao, B Leong, JD Messinger, D Kar… - … & visual science, 2021 - tvst.arvojournals.org
Purpose: By optical coherence tomography (OCT) imaging, hyperreflective foci (HRF)
indicate progression risk for advanced age-related macular degeneration (AMD) and are in …
indicate progression risk for advanced age-related macular degeneration (AMD) and are in …
On phagocytes and macular degeneration
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …
interplay of age and genetic and environmental risk factors. A common feature observed in …