Pituitary tumor-transforming gene: physiology and implications for tumorigenesis

G Vlotides, T Eigler, S Melmed - Endocrine reviews, 2007 - academic.oup.com
Pituitary tumor-transforming gene-1 (PTTG1) is overexpressed in a variety of endocrine-
related tumors, especially pituitary, thyroid, breast, ovarian, and uterine tumors, as well as …

Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases

HC Chi, CY Tsai, MM Tsai, CT Yeh, KH Lin - Journal of biomedical science, 2019 - Springer
The liver is controlled by several metabolic hormones, including thyroid hormone, and
characteristically displays high lysosomal activity as well as metabolic stress-triggered …

Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update

F Salehi, K Kovacs, BW Scheithauer… - Endocrine-Related …, 2008 - erc.bioscientifica.com
The gene expression grade index (GGI) is a 97-gene algorithm that measures proliferation
and divides intermediate histological grade tumors into two distinct groups. We investigated …

Molecular functions of thyroid hormones and their clinical significance in liver‐related diseases

HC Chi, CY Chen, MM Tsai, CY Tsai… - BioMed research …, 2013 - Wiley Online Library
Thyroid hormones (THs) are potent mediators of several physiological processes, including
embryonic development, cellular differentiation, metabolism, and cell growth …

[PDF][PDF] Usefulness of serum thyroid-stimulation hormone (TSH) as a prognostic indicator for acute-on-chronic liver failure

Y Wu, S You, H Zang, H Liu, Y Mao, P Mao… - Annals of …, 2015 - medigraphic.com
Background and rationale for the study. To investigate thyroid function in patients with acute-
on-chronic liver failure (ACLF) caused by hepatitis B virus infection and to determine …

The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell …

IP Pogribny, L Muskhelishvili, VP Tryndyak… - Toxicology and applied …, 2009 - Elsevier
The aromatic amine 2-acetylaminofluore (2-AAF) is a powerful complete genotoxic rat liver
carcinogen that induces tumors without any additional interventions. While the tumor …

Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer

M Xu, L Dong, P Qi, W Weng, X Shen, S Ni, D Huang… - Gastric Cancer, 2016 - Springer
Background Pituitary tumor-transforming gene-1 (PTTG1) is a transcription factor that can
affect transcriptional activity, angiogenesis, and cell senescence. We examined PTTG1 …

The pituitary tumour‐transforming gene 1/delta‐like homologue 1 pathway plays a key role in liver fibrogenesis

M Perramón, S Carvajal, V Reichenbach… - Liver …, 2022 - Wiley Online Library
Background and Aims PTTG1 is almost undetectable in adult livers but is highly expressed
in hepatocarcinoma. While little is known about its involvement in liver fibrosis, PTTG1 …

Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma

RN Chen, YH Huang, CT Yeh, CH Liao, KH Lin - Cancer research, 2008 - AACR
Pituitary tumor transforming gene 1 (PTTG1) is expressed in most tumors. However, whether
thyroid hormone (T3) and its receptors (TR) regulate PTTG1 in human hepatocellular …

Pituitary tumor transforming gene 1 regulates Aurora kinase A activity

Y Tong, A Ben-Shlomo, C Zhou, K Wawrowsky… - Oncogene, 2008 - nature.com
Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in
several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases …