[HTML][HTML] History and progress of hypotheses and clinical trials for Alzheimer's disease
PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
[HTML][HTML] Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes
M Michailidis, D Moraitou, DA Tata, K Kalinderi… - International journal of …, 2022 - mdpi.com
Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD)
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …
[HTML][HTML] The key role of mitochondrial function in health and disease
I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
Microvascular dysfunction in diabetes mellitus and cardiometabolic disease
WB Horton, EJ Barrett - Endocrine reviews, 2021 - academic.oup.com
This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …
Type 2 diabetes and cognitive dysfunction—towards effective management of both comorbidities
V Srikanth, AJ Sinclair, F Hill-Briggs… - The lancet Diabetes & …, 2020 - thelancet.com
Type 2 diabetes and cognitive dysfunction are highly prevalent disorders worldwide.
Although type 2 diabetes is associated with an increased risk of dementia, awareness of the …
Although type 2 diabetes is associated with an increased risk of dementia, awareness of the …
[HTML][HTML] Altered insulin signaling in Alzheimer's disease brain–special emphasis on PI3K-Akt pathway
S Gabbouj, S Ryhänen, M Marttinen… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective …
prevalence in aging populations. T2D, characterized by insulin resistance and defective …
[HTML][HTML] Impact of metabolic syndrome on neuroinflammation and the blood–brain barrier
P Van Dyken, B Lacoste - Frontiers in neuroscience, 2018 - frontiersin.org
Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread
medical conditions. It induces systemic inflammation, causing far reaching effects on the …
medical conditions. It induces systemic inflammation, causing far reaching effects on the …
Hippocampal insulin resistance and cognitive dysfunction
GJ Biessels, LP Reagan - Nature Reviews Neuroscience, 2015 - nature.com
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
Impact of diabetes on cognitive function and brain structure
A Moheet, S Mangia… - Annals of the New York …, 2015 - Wiley Online Library
Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …
multiple domains of cognitive function and with structural abnormalities in the brain. With an …
White matter hyperintensities and imaging patterns of brain ageing in the general population
White matter hyperintensities are associated with increased risk of dementia and cognitive
decline. The current study investigates the relationship between white matter …
decline. The current study investigates the relationship between white matter …