Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …

Brown fat is emerging as an interesting and promising target for therapeutic intervention in
obesity and metabolic disease. Activation of brown fat in humans is associated with marked …

Our understanding of thyroid hormone action has been substantially altered by recent
clinical observations of thyroid signaling defects in syndromes of hormone resistance and in …

Thyroid hormone signalling regulates crucial biological functions, including energy
expenditure, thermogenesis, development and growth. The skeletal muscle is a major target …

Although weight loss can usually be achieved by restricting food intake, the majority of
dieters regain weight over the long-term. In the hypothalamus, hormonal signals from the …

Obesity, type 2 diabetes, and heart failure are associated with aberrant cardiac metabolism.
We show that the heart regulates systemic energy homeostasis via MED13, a subunit of the …

The incidence of the metabolic syndrome has reached epidemic levels in the Western world.
With respect to the energy balance, most attention has been given to reducing energy (food) …

Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and
thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic …

Context Recently, reduced sensitivity to thyroid hormone as a more common finding in the
general population and its possible association with metabolic parameters has been the …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …