IHF and HU: flexible architects of bent DNA

KK Swinger, PA Rice - Current opinion in structural biology, 2004 - Elsevier
The energetic cost of bending short segments of DNA is very high. This bending is critical for
the packaging of DNA and is exploited to regulate many cellular processes. In prokaryotes …

The role of nucleoid‐associated proteins in the organization and compaction of bacterial chromatin

RT Dame - Molecular microbiology, 2005 - Wiley Online Library
The bacterial chromosomal DNA is folded into a compact structure called nucleoid. The
shape and size of this 'body'is determined by a number of factors. Major players are DNA …

Optical tweezers analysis of DNA–protein complexes

I Heller, TP Hoekstra, GA King, EJG Peterman… - Chemical …, 2014 - ACS Publications
Cellular DNA is continuously engaged in a molecular dance with many accessory proteins.
These proteins are responsible for orchestrating the storage, maintenance, and transfer of …

Dual architectural roles of HU: formation of flexible hinges and rigid filaments

J van Noort, S Verbrugge, N Goosen… - Proceedings of the …, 2004 - National Acad Sciences
The nucleoid-associated protein HU is one of the most abundant proteins in Escherichia coli
and has been suggested to play an important role in bacterial nucleoid organization and …

Association of nucleoid proteins with coding and non-coding segments of the Escherichia coli genome

DC Grainger, D Hurd, MD Goldberg… - Nucleic acids …, 2006 - academic.oup.com
The Escherichia coli chromosome is condensed into an ill-defined structure known as the
nucleoid. Nucleoid-associated DNA-binding proteins are involved in maintaining this …

The architectural role of nucleoid-associated proteins in the organization of bacterial chromatin: a molecular perspective

MS Luijsterburg, MC Noom, GJL Wuite… - Journal of structural …, 2006 - Elsevier
The bacterial genome is folded into a compact structure called the nucleoid. Considerable
compaction of the DNA molecule is required in order to reduce its volume below that of the …

Regulation of gene expression by histone-like proteins in bacteria

CJ Dorman, P Deighan - Current opinion in genetics & development, 2003 - Elsevier
Histone-like proteins in bacteria contribute to the control of gene expression, as well as
participating in other DNA transactions such as recombination and DNA replication. They …

Increased bending rigidity of single DNA molecules by H-NS, a temperature and osmolarity sensor

R Amit, AB Oppenheim, J Stavans - Biophysical journal, 2003 - cell.com
Histonelike nucleoid structuring protein (H-NS) is an abundant prokaryotic protein
participating in nucleoid structure, gene regulation, and silencing. It plays a key role in cell …

Biophysical characterization of DNA binding from single molecule force measurements

KR Chaurasiya, T Paramanathan, MJ McCauley… - Physics of life …, 2010 - Elsevier
Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

The bacterial nucleoid: a highly organized and dynamic structure

M Thanbichler, SC Wang… - Journal of cellular …, 2005 - Wiley Online Library
Recent advances in bacterial cell biology have revealed unanticipated structural and
functional complexity, reminiscent of eukaryotic cells. Particular progress has been made in …