Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …

Studying the role of essential proteins is dependent upon a method for rapid inactivation, in
order to study the immediate phenotypic consequences. Auxin-inducible degron (AID) …

Glioblastoma therapies have remained elusive due to limitations in understanding
mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 …

The WD40-containing E3 ubiquitin ligase RFWD3 has been recently linked to the repair of
DNA damage by homologous recombination (HR). Here we have shown that an RFWD3 …

Premature ovarian failure (POF) is a genetically and phenotypically heterogeneous disorder
that includes individuals with manifestations ranging from primary amenorrhea to loss of …

RFWD3 is a recently identified Fanconi anemia protein FANCW whose E3 ligase activity
toward RPA is essential in homologous recombination (HR) repair. However, how RPA …

Premature ovarian failure (POF) is genetically heterogeneous and manifests as
hypergonadotropic hypogonadism either as part of a syndrome or in isolation. We studied …

Interstrand DNA crosslinks (ICLs) are the link between Watson-Crick strands of DNAs with
the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both …

Despite the recent advances in cancer research and treatment, gastrointestinal (GI) cancers
remain the most common deadly disease worldwide. The aberrant DNA replication serves …