Heart failure with preserved ejection fraction: JACC scientific statement

BA Borlaug, K Sharma, SJ Shah, JE Ho - Journal of the American College …, 2023 - Elsevier
The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF)
continue to rise in tandem with the increasing age and burdens of obesity, sedentariness …

Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

BA Borlaug, MD Jensen, DW Kitzman… - Cardiovascular …, 2022 - academic.oup.com
Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models

J Roh, JA Hill, A Singh, M Valero-Muñoz… - Circulation …, 2022 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

The pathophysiology of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2014 - nature.com
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …

Inflammation in metabolic cardiomyopathy

FA Wenzl, S Ambrosini, SA Mohammed… - Frontiers in …, 2021 - frontiersin.org
Overlapping pandemics of lifestyle-related diseases pose a substantial threat to
cardiovascular health. Apart from coronary artery disease, metabolic disturbances linked to …

Cardiac metabolism in HFpEF: from fuel to signalling

F Capone, C Sotomayor-Flores, D Bode… - Cardiovascular …, 2022 - academic.oup.com
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Pathophysiological basis of the cardiological benefits of SGLT-2 inhibitors: a narrative review

C Panico, B Bonora, A Camera, NC Chilelli… - Cardiovascular …, 2023 - Springer
In recent years, GLP-1 receptor agonists (GLP-1RA), and SGLT-2 inhibitors (SGLT-2i) have
become available, which have become valuable additions to therapy for type 2 diabetes as …

Immunometabolic mechanisms of heart failure with preserved ejection fraction

GG Schiattarella, P Alcaide, G Condorelli… - Nature cardiovascular …, 2022 - nature.com
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide,
already accounting for at least half of all cases of heart failure. As most patients with HFpEF …

[HTML][HTML] Glycolipid metabolic disorders, metainflammation, oxidative stress, and cardiovascular diseases: unraveling pathways

EP de Lima, RC Moretti Jr, K Torres Pomini… - Biology, 2024 - mdpi.com
Simple Summary Glycolipid metabolic disorders (GLMDs) result from imbalances in
glycolipid levels, leading to various health issues, including obesity, diabetes, liver …

Chronic low‐grade inflammation in heart failure with preserved ejection fraction

T Mesquita, YN Lin, A Ibrahim - Aging Cell, 2021 - Wiley Online Library
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form
of HF with a dramatic increase in risk with age. Low‐grade inflammation, as occurs with …