Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

In the last years there has been a considerable advance in the knowledge on the regulation
of astrocytes by sex steroids under physiological and pathological conditions. By the …

The aromatase cytochrome P450 (P450arom) enzyme, or estrogen synthase, which is
coded by the CYP19A1 gene, is widely expressed in a subpopulation of excitatory and …

The brain has high energy requirements to maintain neuronal activity. Consequently
impaired mitochondrial function will lead to disease. Normal aging is associated with several …

Alzheimer's disease (AD) is an age-related neurodegenerative disease marked by a
progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and …

Modulation of autophagy has been increasingly regarded as a promising cancer therapeutic
approach. In this study, we screened several ginsenosides extracted from Panax ginseng …

Aim The present study aims to identify selective estrogen receptor beta (ERβ) agonists and
to evaluate the neuroprotective mechanism in Parkinson's disease (PD) models. Main …

The co-presence of mycotoxins from fungi of the genus Fusarium is a common fact in raw
food and food products, as trace levels of them or their metabolites can be detected, unless …

Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to
females, with a ratio of affected boys compared to girls of 4: 1 for ASD and 11: 1 for Asperger …

Background Tibolone is a synthetic steroid used in clinical practice for the treatment of
climacteric symptoms and osteoporosis. Active metabolites of tibolone, generated in target …