[HTML][HTML] TGF-β1 induces formation of TSG-6-enriched extracellular vesicles in fibroblasts which can prevent myofibroblast transformation by modulating Erk1/2 …
Extracellular vesicles have emerged as important mediators of cell-to-cell communication in
the pathophysiology of fibrotic diseases. One such disease is Peyronie's disease (PD), a …
the pathophysiology of fibrotic diseases. One such disease is Peyronie's disease (PD), a …
Statins synergize with phosphodiesterase type 5 inhibitors but not with selective estrogen receptor modulators to prevent myofibroblast transformation in an in vitro …
Background Peyronie's disease (PD) is a fibrotic disorder characterized by plaque formation
in the tunica albuginea (TA) of the penis, and we have previously shown that inhibition of …
in the tunica albuginea (TA) of the penis, and we have previously shown that inhibition of …
A combination of phosphodiesterase type 5 inhibitor and tamoxifen for acute Peyronie's disease: the first clinical signals
Peyronie's disease (PD) is a fibrotic disorder of the penile tunica albuginea (TA) and can
lead to pain during erection and/or intercourse, penile curvature, erectile dysfunction, and …
lead to pain during erection and/or intercourse, penile curvature, erectile dysfunction, and …
Temporal gene signature of myofibroblast transformation in Peyronie's disease: first insights into the molecular mechanisms of irreversibility
MM Ilg, S Harding, AR Lapthorn, S Kirvell… - The Journal of …, 2024 - academic.oup.com
Background Transformation of resident fibroblasts to profibrotic myofibroblasts in the tunica
albuginea is a critical step in the pathophysiology of Peyronie's disease (PD). We have …
albuginea is a critical step in the pathophysiology of Peyronie's disease (PD). We have …
Statins synergize with other drugs to prevent myofibroblast transformation in in vitro model of peyronie's disease
Objectives Peyronie's disease is characterized by formation of a plaque in the tunica
albuginea (TA), with myofibroblasts being the main effector cells. We have previously shown …
albuginea (TA), with myofibroblasts being the main effector cells. We have previously shown …
Investigating the role of phosphodiesterases in myofibroblast transformation in Peyronie's disease
S Harding - 2024 - aru.figshare.com
Introduction: Peyronie's disease (PD) is characterised by a fibrous plaque that forms in the
penile tunica albuginea (TA), leading to pain, penile deformity, and erectile dysfunction …
penile tunica albuginea (TA), leading to pain, penile deformity, and erectile dysfunction …
[HTML][HTML] Old drugs, new uses: advances in drug repurposing and the federal outlook
N Davies - thepharmaletter.com
In June 2021, the US Food and Drug Administration (FDA) approved Novo Nordisk's (NOV:
N) type 2 diabetes drug Wegovy (semaglutide) injection for chronic weight management in …
N) type 2 diabetes drug Wegovy (semaglutide) injection for chronic weight management in …