Background Sensitivity analyses play a crucial role in assessing the robustness of the
findings or conclusions based on primary analyses of data in clinical trials. They are a critical …

Aims To synthesise the available body of qualitative studies relating to clinical research
nurses' experiences of their role. Methods A systematic search of the literature in five …

Background A number of single case reports have suggested that the context within which
intervention studies take place may challenge the assumptions that underpin randomised …

Background Implementing the treatment arm of a clinical trial often requires changes to
healthcare practices. Barriers to such changes may undermine the delivery of the treatment …

Abstract Objectives To evaluate the Flinders Program in improving self-management in
common chronic conditions. To examine properties of the Partners in Health scale (PIH) …

Background Understanding intervention fidelity is an essential part of the evaluation of
complex interventions because fidelity not only affects the validity of trial findings, but also …

The introduction of new sequencing technologies whole-genome sequencing (WGS) and
whole-exome sequencing (WES) that are much less finely targeted than previous genetic …

Background There is increasing recognition among trialists of the challenges in
understanding how particular 'real-life'contexts influence the delivery and receipt of complex …

Background The perspectives and experiences of trial staff are increasingly being
investigated as these can be used to improve recruitment, adherence to trial protocols and …

Background: This study evaluated the effectiveness of a screening and stepped care
program (the TES program) in reducing psychological distress compared with care as usual …