The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …

Abstract Intracellular Vitamin C (VC) is maintained at high levels in the developing brain by
the activity of sodium-dependent VC transporter 2 (Svct2), suggesting specific VC functions …

Successful clinical translation of stem cell-based therapy largely relies on the scalable and
reproducible preparation of donor cells with potent therapeutic capacities. In this study …

Understanding how dopamine (DA) phenotypes are acquired in midbrain DA (mDA) neuron
development is important for bioassays and cell replacement therapy for mDA neuron …

Cell culture of human-derived neural stem cells (NSCs) is a useful tool that contributes to our
understanding of human brain development and allows for the development of therapies for …

Developmental information aids stem cell biologists in producing tissue-specific cells.
Recapitulation of the developmental profile of a specific cell type in an in vitro stem cell …

NURR1 is an essential transcription factor for the differentiation, maturation, and
maintenance of midbrain dopaminergic neurons (DA neurons) as it has been demonstrated …

The transcription factor Nurr1 is expressed in the mouse olfactory bulb (OB), although it
remains unknown whether it influences the generation of dopaminergic neurons (DA)(DA …

Cardiac stem cells (CSCs)-based therapy provides a promising avenue for the management
of ischemic heart diseases. However, engrafted CSCs are subjected to acute cell apoptosis …