The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Cell division is a complex process with high energy demands. However, how cells regulate
the generation of energy required for DNA synthesis and chromosome segregation is not …

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …

Tissue stem cells undergo premature senescence under stress, promoting age-related
diseases; however, the associated mechanisms remain unclear. Here, we report that in …

Background Increasing evidence showed that miRNAs serve as modulators of human
cancer, either as oncogene or tumor suppressors. Cisplatin resistance is the most common …

During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or
permanent G0 in which they are refractory to mitogenic signals. Entry into G0 is usually …

Specific cellular functions, such as proliferation, survival, growth, or senescence, require a
particular adaptive metabolic response, which is fine tuned by members of the cell cycle …

Declining mitochondrial function and homeostasis is a hallmark of aging. It is appreciated
that the role of mitochondria is much more complex than generating reactive oxygen species …

Many of the regulatory features governing erythrocyte specification, maturation, and
associated disorders remain enigmatic. To identify new regulators of erythropoiesis, we …

The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to
regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7 …