Chemical carcinogenesis follows a multistep process involving both mutation and increased
cell proliferation. Oxidative stress can occur through overproduction of reactive oxygen and …

Abstract Hydrogen peroxide (H 2 O 2) is a powerful oxidising agent. It gives rise to agents
known to be effective bleaching agents. The mechanisms of bleaching involve the …

Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the
environment. These contaminants generate considerable interest, because some of them …

Widely varied chemicals—including certain herbicides, plasticizers, drugs, and natural
products—induce peroxisome proliferation in rodent liver and other tissues. This …

Networks of blood vessels in normal and tumour tissues have heterogeneous structures,
with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution …

Killing of unirradiated cells by medium from cultures of irradiated cells implies the release of
a cytotoxic substance by the irradiated cells. The finding of the γ-ray-induced cytotoxic effect …

Multiple lines of evidences suggest that oxidative stress induced by reactive oxygen species
are closely related to multi-stage carcinogenesis. Polyphenols, a group of chemicals with …

Gap junctional intercellular communication (GJIC) is the major pathway of intercellular
signal transduction, and is thus important for normal cell growth and function. Recent studies …

Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …

Several studies have reported that even a moderate daily dose of supplementary vitamin C
(200 mg) induces the formation of genotoxins from lipid hydroperoxides, thereby resulting in …