[HTML][HTML] Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics

NK Gatselis, K Zachou, GK Koukoulis… - World journal of …, 2015 - ncbi.nlm.nih.gov
Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology
characterized by hypergammaglobulinemia, autoantibodies detection and interface …

[HTML][HTML] Diagnosis and management of autoimmune hepatitis: current status and future directions

AJ Czaja - Gut and liver, 2016 - ncbi.nlm.nih.gov
Autoimmune hepatitis is characterized by autoantibodies, hypergammaglobulinemia, and
interface hepatitis on histological examination. The features lack diagnostic specificity, and …

Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of …

CL Mack, D Adams, DN Assis, N Kerkar… - …, 2020 - Wiley Online Library
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALF, acute liver failure; ALT, alanine aminotransferase; AMA …

autoimmune hepatitis–current management and challenges

K Zachou, P Muratori, GK Koukoulis… - Alimentary …, 2013 - Wiley Online Library
Background Autoimmune hepatitis (AIH) is a disease of unknown aetiology characterised by
interface hepatitis, hypergammaglobulinaemia, circulating autoantibodies and a favourable …

Cellular and molecular mechanisms of autoimmune hepatitis

GJ Webb, GM Hirschfield, EL Krawitt… - Annual Review of …, 2018 - annualreviews.org
Autoimmune hepatitis is an uncommon idiopathic syndrome of immune-mediated
destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is …

Mycophenolate for the treatment of autoimmune hepatitis: prospective assessment of its efficacy and safety for induction and maintenance of remission in a large …

K Zachou, N Gatselis, G Papadamou, EI Rigopoulou… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Standard therapy for autoimmune hepatitis (AIH) is corticosteroids
with or without azathioprine. However, 20% of patients do not respond or are intolerant to …

Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

CS Umeshappa, S Singha, J Blanco, K Shao… - Nature …, 2019 - nature.com
Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying
tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re …

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

M Holdener, E Hintermann, M Bayer, A Rhode… - The Journal of …, 2008 - rupress.org
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary
cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate …

Autoimmune hepatitis: serum autoantibodies in clinical practice

B Terziroli Beretta-Piccoli, G Mieli-Vergani… - Clinical reviews in …, 2022 - Springer
Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being
positive in 95% of the cases if tested according to dedicated guidelines issued by the …

The contribution of B cells in autoimmune liver diseases

SA Taylor, DN Assis, CL Mack - Seminars in liver disease, 2019 - thieme-connect.com
Autoreactive B cells can promote autoimmunity through antigen presentation to autoreactive
T cells, production of autoantibodies, generation of cytokines promoting T cell activation and …