Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond

M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

[HTML][HTML] Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families

M Simard, AS Archambault, JPC Lavoie… - Biochemical …, 2022 - Elsevier
Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …

[HTML][HTML] Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS

A Kouchaeknejad, G Van Der Walt… - International journal of …, 2023 - mdpi.com
As central nervous system (CNS)-related disorders present an increasing cause of global
morbidity, mortality, and high pressure on our healthcare system, there is an urgent need for …