Hepatic stellate cells in physiology and pathology
DR Kamm, KS McCommis - The Journal of physiology, 2022 - Wiley Online Library
Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …
Confronting false discoveries in single-cell differential expression
Differential expression analysis in single-cell transcriptomics enables the dissection of cell-
type-specific responses to perturbations such as disease, trauma, or experimental …
type-specific responses to perturbations such as disease, trauma, or experimental …
[HTML][HTML] In vitro models for the study of liver biology and diseases: advances and limitations
In vitro models of liver (patho) physiology, new technologies, and experimental approaches
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …
Sex-biased gene expression across mammalian organ development and evolution
L Rodríguez-Montes, S Ovchinnikova, X Yuan, T Studer… - Science, 2023 - science.org
Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …
development through the deployment of sex-specific genetic programs. Because little is …
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis
Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated
cytokine pathways leading to elevated chemokine expression. Super-enhancers are …
cytokine pathways leading to elevated chemokine expression. Super-enhancers are …
Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
ML Richter, IK Deligiannis, K Yin, A Danese… - Nature …, 2021 - nature.com
Single-cell RNA-seq reveals the role of pathogenic cell populations in development and
progression of chronic diseases. In order to expand our knowledge on cellular …
progression of chronic diseases. In order to expand our knowledge on cellular …
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge
E Sanchez-Quant, ML Richter, M Colomé-Tatché… - Genome Biology, 2023 - Springer
Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary
human hepatocytes are the gold standard model for the assessment of drug efficacy, safety …
human hepatocytes are the gold standard model for the assessment of drug efficacy, safety …
Epigenetic regulation of hepatic lipid metabolism by DNA methylation
While extensive investigations have been devoted to the study of genetic pathways related
to fatty liver diseases, much less is known about epigenetic mechanisms underlying these …
to fatty liver diseases, much less is known about epigenetic mechanisms underlying these …
Interplay between GH-regulated, sex-biased liver transcriptome and hepatic zonation revealed by single-nucleus RNA sequencing
The zonation of liver metabolic processes is well-characterized; however, little is known
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …
Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …