Intracranial self-stimulation to evaluate abuse potential of drugs
SS Negus, LL Miller - Pharmacological reviews, 2014 - ASPET
Intracranial self-stimulation (ICSS) is a behavioral procedure in which operant responding is
maintained by pulses of electrical brain stimulation. In research to study abuse-related drug …
maintained by pulses of electrical brain stimulation. In research to study abuse-related drug …
Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology
LJ De Felice, RA Glennon, SS Negus - Life sciences, 2014 - Elsevier
This mini-review summarizes the history of cathinone and its synthesized derivatives from
early records to the present day, including the appearance of synthetic cathinones in the …
early records to the present day, including the appearance of synthetic cathinones in the …
Abuse-related and abuse-limiting effects of methcathinone and the synthetic “bath salts” cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and …
JS Bonano, RA Glennon, LJ De Felice, ML Banks… - …, 2014 - Springer
Rationale Abuse of synthetic cathinones, popularized as “bath salts,” has increased
dramatically in the USA since their debut in 2010. Preclinical behavioral studies may clarify …
dramatically in the USA since their debut in 2010. Preclinical behavioral studies may clarify …
Quantitative structure–activity relationship analysis of the pharmacology of para‐substituted methcathinone analogues
JS Bonano, ML Banks, R Kolanos… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Methcathinone (MCAT) is a potent monoamine releaser and
parent compound to emerging drugs of abuse including mephedrone (4‐CH 3 MCAT), the …
parent compound to emerging drugs of abuse including mephedrone (4‐CH 3 MCAT), the …
Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia
SA Barnes, A Der-Avakian, A Markou - European …, 2014 - Elsevier
Schizophrenia represents a complex, heterogeneous disorder characterized by several
symptomatic domains that include positive and negative symptoms and cognitive deficits …
symptomatic domains that include positive and negative symptoms and cognitive deficits …
Synthetic cathinones and their rewarding and reinforcing effects in rodents
LR Watterson, MF Olive - Advances in Neuroscience, 2014 - Wiley Online Library
Synthetic cathinones, colloquially referred to as “bath salts,” are derivatives of the
psychoactive alkaloid cathinone found in Catha edulis (Khat). Since the mid‐to‐late 2000s …
psychoactive alkaloid cathinone found in Catha edulis (Khat). Since the mid‐to‐late 2000s …
Expression and treatment of pain-related behavioral depression
SS Negus - Lab animal, 2013 - nature.com
Pain is often associated with clinically relevant depression of behavior and mood, and relief
of pain-related depression is a common goal of treatment in both human and veterinary …
of pain-related depression is a common goal of treatment in both human and veterinary …
Effects of α‐pyrrolidinopentiophenone and 4-methyl-n-ethylcathinone, two synthetic cathinones commonly found in second-generation “bath salts,” on intracranial self …
LR Watterson, BT Burrows… - International Journal …, 2015 - academic.oup.com
Background: Use of synthetic cathinones, which are designer stimulants found in “bath
salts,” has increased dramatically in recent years. Following governmental bans of …
salts,” has increased dramatically in recent years. Following governmental bans of …
Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats
AW Bruijnzeel, JC Alexander, PD Perez… - International Journal …, 2015 - academic.oup.com
Background: Acute nicotine administration potentiates brain reward function and enhances
motor and cognitive function. These studies investigated which brain areas are being …
motor and cognitive function. These studies investigated which brain areas are being …
Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats
TM Hillhouse, JH Porter, SS Negus - Psychopharmacology, 2014 - Springer
Rationale The noncompetitive NMDA antagonist ketamine produces rapid antidepressant
effects in treatment-resistant patients suffering from major depressive and bipolar disorders …
effects in treatment-resistant patients suffering from major depressive and bipolar disorders …