A guide to: generation and design of nanobodies
S Muyldermans - The FEBS journal, 2021 - Wiley Online Library
A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …
A comparison of the innate and adaptive immune systems in cartilaginous fish, ray-finned fish, and lobe-finned fish
NC Smith, ML Rise, SL Christian - Frontiers in immunology, 2019 - frontiersin.org
The immune system is composed of two subsystems—the innate immune system and the
adaptive immune system. The innate immune system is the first to respond to pathogens and …
adaptive immune system. The innate immune system is the first to respond to pathogens and …
Elephant shark genome provides unique insights into gnathostome evolution
The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was
accompanied by major morphological and physiological innovations, such as hinged jaws …
accompanied by major morphological and physiological innovations, such as hinged jaws …
Fish immunoglobulins
S Mashoof, MF Criscitiello - Biology, 2016 - mdpi.com
The B cell receptor and secreted antibody are at the nexus of humoral adaptive immunity. In
this review, we summarize what is known of the immunoglobulin genes of jawed …
this review, we summarize what is known of the immunoglobulin genes of jawed …
Protective roles of natural IgM antibodies
C Grönwall, J Vas, GJ Silverman - Frontiers in immunology, 2012 - frontiersin.org
Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-
tuning of the recognition and response to foreign threats. However, in health there are some …
tuning of the recognition and response to foreign threats. However, in health there are some …
Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications
Y Wang, Z Fan, L Shao, X Kong, X Hou… - International journal …, 2016 - Taylor & Francis
Owing to peculiar properties of nanobody, including nanoscale size, robust structure, stable
and soluble behaviors in aqueous solution, reversible refolding, high affinity and specificity …
and soluble behaviors in aqueous solution, reversible refolding, high affinity and specificity …
How antibodies fold
B cells use unconventional strategies for the production of a seemingly unlimited number of
antibodies from a very limited amount of DNA. These methods dramatically increase the …
antibodies from a very limited amount of DNA. These methods dramatically increase the …
A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?
MF Flajnik, N Deschacht, S Muyldermans - PLoS biology, 2011 - journals.plos.org
The success of our adaptive humoral immune response, mediated by B cells, relies on its
capacity to produce multiple antigen-recognition specificities against any possible invader …
capacity to produce multiple antigen-recognition specificities against any possible invader …
Adverse effects of plastic ingestion on the Mediterranean small-spotted catshark (Scyliorhinus canicula)
Plastics are widely diffused in the oceans and their ingestion by marine organisms is raising
concern for potentially adverse effects. The risk of harmful interactions with marine plastic …
concern for potentially adverse effects. The risk of harmful interactions with marine plastic …
[HTML][HTML] Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers
The absence of germinal centers (GCs) in cartilaginous fishes lies at odds with data showing
that nurse sharks can produce robust antigen-specific responses and affinity mature their B …
that nurse sharks can produce robust antigen-specific responses and affinity mature their B …