A hallmark of polarity in most migrating cells is the orientation of the nuclear centrosomal
(NC) axis relative to the front–back cellular axis. Here, we review 'effector functions' …

The centrosome, a major organizer of microtubules, has important functions in regulating
cell shape, polarity, cilia formation and intracellular transport as well as the position of …

Purpose Male infertility remains poorly understood at the molecular level. We aimed in this
study to investigate the yield of a “genomics first” approach to male infertility. Methods …

Primary cilia are immotile organelles known for their roles in development and cell signaling.
Defects in primary cilia result in a range of disorders named ciliopathies. Because this …

Cell polarity identifies the asymmetry of a cell. Various types of cells, including odontoblasts
and epithelial cells, polarize to fulfil their destined functions. Odontoblast polarization is a …

Ectocarpus is a genus of filamentous, marine brown algae. Brown algae belong to the
stramenopiles, a large supergroup of organisms that are only distantly related to animals …

Model organisms are extensively used in research as accessible and convenient systems
for studying a particular area or question in biology. Traditionally, only a limited number of …

Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk
loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 …

The retinal pigment epithelium (RPE) constitutes a monolayer of cuboidal cells that interact
apically with the interphotoreceptor matrix (IPM) and outer segments of the photoreceptor …

The ARF family of regulatory GTPases is ancient, with 16 members predicted to have been
present in the last eukaryotic common ancestor. Our phylogenetic profiling of paralogues in …