Total body irradiation or chemotherapy conditioning in childhood ALL: a multinational, randomized, noninferiority phase III study
C Peters, JH Dalle, F Locatelli, U Poetschger… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Total body irradiation (TBI) before allogeneic hematopoietic stem cell
transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is …
transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is …
Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review
AL Myers, JD Kawedia, RE Champlin… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Busulfan (Bu) is an alkylating agent with a limited therapeutic
margin and exhibits inter-patient variability in pharmacokinetics (PK). Despite decades of …
margin and exhibits inter-patient variability in pharmacokinetics (PK). Despite decades of …
Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: preclinical and clinical data
Seizures are relatively common in cancer patients, and co-administration of
chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many …
chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many …
[HTML][HTML] Association between the magnitude of intravenous busulfan exposure and development of hepatic veno-occlusive disease in children and young adults …
T Bognàr, IH Bartelink, TCG Egberts… - … and Cellular Therapy, 2022 - Elsevier
Intravenous busulfan is widely used as part of myeloablative conditioning regimens in
children and young adults undergoing allogeneic hematopoietic cell transplantation (HCT) …
children and young adults undergoing allogeneic hematopoietic cell transplantation (HCT) …
Pharmacokinetic behavior and appraisal of intravenous busulfan dosing in infants and older children: the results of a population pharmacokinetic study from a large …
Background Intravenous (IV) busulfan (Bu) dosing approved in Europe based on 5 body
weight (BW) strata has been validated for targeting Bu exposures in children undergoing …
weight (BW) strata has been validated for targeting Bu exposures in children undergoing …
[HTML][HTML] GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study
Busulfan (BU) dose adjustment following therapeutic drug monitoring contributes to better
outcome of hematopoietic stem cell transplantation (HSCT). Further improvement could be …
outcome of hematopoietic stem cell transplantation (HSCT). Further improvement could be …
[HTML][HTML] Highly variable pharmacokinetics of once-daily intravenous busulfan when combined with fludarabine in pediatric patients: phase I clinical study for …
JW Lee, HJ Kang, SH Lee, KS Yu, NH Kim… - Biology of Blood and …, 2012 - Elsevier
Busulfan has a narrow therapeutic range, and in children, pharmacokinetic variability has
been found to be high even after the use of intravenous (iv) busulfan. Recently, a reduced …
been found to be high even after the use of intravenous (iv) busulfan. Recently, a reduced …
[HTML][HTML] Association between gene polymorphisms in the cyclophosphamide metabolism pathway with complications after haploidentical hematopoietic stem cell …
P Muñiz, C Andrés-Zayas, D Carbonell… - Frontiers in …, 2022 - frontiersin.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for
patients with hematologic malignances. Haploidentical HSCT (Haplo-HSCT) is an …
patients with hematologic malignances. Haploidentical HSCT (Haplo-HSCT) is an …
Individualizing busulfan dose in specific populations and evaluating the risk of pharmacokinetic drug-drug interactions
D Combarel, J Tran, J Delahousse… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Busulfan is an alkylating agent widely used in the conditioning of hematopoietic
stem cell transplantation possessing a complex metabolism and a large interindividual and …
stem cell transplantation possessing a complex metabolism and a large interindividual and …
Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation
Aims The aim of this study is to develop a population pharmacokinetic (PopPK) model for
intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the …
intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the …