Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Disruption of the cellular pathway modulating endogenous 24-h rhythms, referred to as “the
circadian clock”, has been recently proven to be associated with cancer risk, development …

The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse
and extensive processes throughout the body. The clock mechanism comprises a core …

The circadian clock is a global regulatory system that interfaces with most other regulatory
systems and pathways in mammalian organisms. Investigations of the circadian clock–DNA …

Circadian timekeeping systems drive oscillatory gene expression to regulate essential
cellular and physiological processes. When the systems are perturbed, pathological …

Circadian rhythms are of crucial importance for cellular and physiological functions of the
brain and body. Chronobiology has a prominent role in rheumatoid arthritis (RA), with major …

The circadian clock directs nearly all aspects of diurnal physiology, including metabolism.
Current research identifies several major axes by which it exerts these effects, including …

Introduction: Disruptions in sleep and circadian rhythms are observed in individuals with
bipolar disorders (BD), both during acute mood episodes and remission. Such abnormalities …

Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the
potential to directly modulate the endogenous circadian rhythm and treat diseases …