The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …

Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Stimulator of interferon genes (STING) is an adaptor protein in innate immunity against DNA
viruses or bacteria,,,–. STING-mediated immunity could be exploited in the development of …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

De novo formation of the double-membrane compartment autophagosome is seeded by
small vesicles carrying membrane protein autophagy-related 9 (ATG9), the function of which …

The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by
self DNA from the nucleus or mitochondria represents a danger signal that alerts the host …